Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histiocytic sarcoma with interdigitating dendritic cell differentiation.

David W Porter1, Girish L Gupte, Rachel M Brown

  • 1Liver Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.

Journal of Pediatric Hematology/Oncology
|December 14, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction-associated steatotic liver disease.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Donor size and early vascular complications in children receiving a whole liver transplant.

World journal of transplantation·2026
Same author

Refractory autoimmune hepatitis in children: Considerations for assessment and management.

World journal of hepatology·2026
Same author

Hormonal risk factors and androgen and glucocorticoid dysregulation in Sjogren's disease and non-Sjogren's sicca.

Rheumatology (Oxford, England)·2025
Same author

Regression of intestinal failure-associated liver disease by alteration of lipid emulsion regime in home parenteral nutrition: A case report.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2025
Same author

Management of hepatic artery thrombosis and stenosis after pediatric liver transplantation: Variability and agreement in management practices.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2025

This study details a rare infant tumor mimicking histiocytic sarcoma and interdigitating dendritic cell sarcoma. Early diagnosis is challenging, necessitating repeat biopsies for unexplained hepatosplenomegaly and thrombocytopenia in children.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Pathology

Background:

  • True histiocytic sarcoma and interdigitating dendritic cell sarcoma are rare malignancies.
  • Tumors with overlapping features pose diagnostic challenges, especially in infants.

Observation:

  • A 3-month-old boy presented with hepatosplenomegaly and abdominal distention.
  • Progressive splenomegaly, thrombocytopenia, and coagulopathy were noted on follow-up.
  • Initial investigations presented a diagnostic challenge.

Findings:

  • A diagnosis of histiocytic sarcoma with interdigitating dendritic cell differentiation was established via liver and spleen biopsy.
  • This rare tumor type presents unique diagnostic hurdles in infancy.

Implications:

Related Experiment Videos

  • Repeat liver and splenic biopsies are recommended for pediatric cases of unexplained hepatosplenomegaly and thrombocytopenia.
  • Highlights the importance of thorough histopathological evaluation for rare infant tumors.
  • Contributes to understanding rare histiocytic neoplasms in early childhood.