Related Experiment Video
Updated: Aug 20, 2026
Development of an In Vitro Ocular Platform to Test Contact Lenses
Published on: April 6, 2016
Short-term physiologic response in neophyte subjects fitted with hydrogel and silicone hydrogel contact lenses
Carole Maldonado-Codina1, Philip B Morgan, Cristina M Schnider
1Eurolens Research, Department of Optometry, The University of Manchester, Manchester, United Kingdom. c.m-codina@manchester.ac.uk
Purpose:
To investigate the short-term physiologic response to three soft lens materials with different oxygen permeability characteristics.
Methods:
Forty-three neophytes were randomly prescribed Acuvue 2, Acuvue Advance (Johnson & Johnson Vision Care), or Focus Night & Day (CIBA Vision) for 4 weeks on a daily-wear basis. A further 19 subjects did not wear lenses (control). Experimental and control subjects were examined 2 and 4 weeks after dispensing. Ocular physiologic response was measured with a slitlamp biomicroscope in a strictly masked fashion.
Results:
Limbal redness increased in the Acuvue 2 group compared with the other two groups. Conjunctival redness increased more in the Acuvue 2 group than in the Acuvue Advance group. More conjunctival staining was seen with the Acuvue Advance and Focus Night & Day groups compared with the Acuvue 2 group. Increased scores for papillary conjunctivitis were seen in the Focus Night & Day group compared with the Acuvue Advance group.
Conclusions:
The reduced level of limbal redness seen with the Acuvue Advance and Focus Night & Day groups suggests that these lenses provide more oxygen to the ocular surface than the Acuvue 2 lens to a degree that can be observed clinically. The conjunctival staining response was similar for the Acuvue Advance and Focus Night & Day groups. The results for the Acuvue Advance and Focus Night & Day groups for papillary conjunctivitis may reflect differences in their material and surface properties.
