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Color Doppler imaging in optic neuritis with multiple sclerosis.
Cengiz Akarsu1, Funda Uysal Tan, Tuba Kendi
1Department of Ophthalmology, University of Kirikkale, 71100 Kirikkale, Turkey. cengizakarsu@hotmail.com
Summary
Multiple sclerosis-related optic neuritis impairs blood flow in the eye's posterior ciliary and central retinal arteries. This study compared hemodynamics in affected eyes, unaffected fellow eyes, and healthy controls.
Area of Science:
- Ophthalmology
- Neurology
- Medical Imaging
Background:
- Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
- Optic neuritis, a common MS symptom, involves inflammation of the optic nerve.
- Understanding retrobulbar hemodynamics in optic neuritis is crucial for disease management.
Purpose of the Study:
- To evaluate retrobulbar hemodynamics in eyes with optic neuritis and MS.
- To compare these hemodynamic values with unaffected fellow eyes and healthy control eyes.
Main Methods:
- Color Doppler imaging was used to measure blood flow velocities and resistivity indices in the ophthalmic, posterior ciliary, and central retinal arteries.
- The study included 17 patients with unilateral optic neuritis and MS, and 16 healthy controls.
- Statistical analysis involved paired and unpaired Student's t-tests.
Main Results:
- Eyes with optic neuritis showed significantly higher resistivity indices in the posterior ciliary and central retinal arteries compared to both unaffected fellow eyes and healthy controls.
- Lower end-diastolic blood flow velocity was observed in the central retinal artery of affected eyes.
- No significant differences in ophthalmic artery hemodynamics were found between groups.
Conclusions:
- Optic neuritis associated with multiple sclerosis leads to impaired retrobulbar hemodynamics.
- The posterior ciliary and central retinal arteries are particularly affected.
- These findings highlight the vascular changes occurring in MS-related optic neuritis.