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Updated: Aug 20, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

[Severe renal failure in a child]

S Maringhini1, M M D'Alessandro, A Di Martino

  • 1UO Nefrologia Pediatrica, ARNAS Ospedale Civico, Di Cristina, Ascoli', Palermo. s.maringhini@ospedalecivicopa.org

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|December 14, 2004
PubMed

Insights

Type I hyperoxaluria caused severe renal failure in a child, necessitating peritoneal dialysis and a subsequent liver-kidney transplant. Successful transplantation normalized renal function and oxalate levels, offering a positive prognosis for rare genetic kidney disease.

Area of Science:

  • Nephrology
  • Medical Genetics
  • Pediatric Gastroenterology

Background:

  • Type I hyperoxaluria is a rare genetic disorder.
  • It leads to excessive oxalate production and deposition in kidneys.
  • This can cause severe kidney damage and failure.

Observation:

  • A four-year-old boy presented with acute severe renal failure.
  • Renal biopsy revealed interstitial infiltration, tubular crystals, and glomerular sclerosis.
  • The patient required peritoneal dialysis (PD) for 10 months.

Findings:

  • Diagnosis of Type I hyperoxaluria was confirmed.
  • The child underwent a combined liver and kidney transplant.
  • Post-transplant, renal function normalized, with blood and urine oxalate levels within normal limits.

Implications:

  • Combined liver-kidney transplantation is an effective treatment for Type I hyperoxaluria.
  • Early diagnosis and intervention are crucial for managing this condition.
  • Successful transplantation offers long-term resolution of renal dysfunction and hyperoxaluria.

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