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Process technologies for purity enhancement of large discovery libraries
Richard S Pottorf1, Mark R Player
1Johnson & Johnson Pharmaceutical Research & Development LLC Drug Discovery, Cranbury, NJ 08512, USA.
Current Opinion in Drug Discovery & Development
|December 15, 2004
Summary
High-quality compound libraries are essential for drug discovery. Recent advances in purification processes are improving the characterization and purification of these libraries for high-throughput screening.
Area of Science:
- Medicinal Chemistry
- Drug Discovery
- Analytical Chemistry
Background:
- Drug discovery relies on structurally diverse compound libraries.
- High-throughput screening (HTS) identifies potential drug candidates (hits).
- Compound quality is critical for successful hit identification and lead optimization.
Purpose of the Study:
- To review recent advancements in purification techniques for combinatorial chemistry.
- To highlight the importance of high-throughput characterization and purification in drug discovery.
Main Methods:
- Literature review of recent purification processes.
- Focus on techniques applicable to combinatorial chemistry.
Main Results:
- Recent advances enhance the efficiency and quality of compound purification.
- Improved purification supports more successful HTS campaigns.
- New methods facilitate the characterization of diverse compound libraries.
Conclusions:
- Effective purification strategies are crucial for modern drug discovery pipelines.
- Advancements in purification directly impact the identification of viable drug leads.
- High-throughput purification is a key enabler for efficient drug development.