Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microfluidic systems for high-throughput and combinatorial chemistry.

Christopher J Cullen1, Robert C R Wootton, Andrew J de Mello

  • 1Imperial College London, Department of Chemistry, South Kensington, London, UK.

Current Opinion in Drug Discovery & Development
|December 15, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization studies of photonic wire bonding for fiber array integration.

Optics express·2026
Same author

A programmable and automated optical electrowetting-on-dielectric (oEWOD) driven platform for massively parallel and sequential processing of single cell assay operations.

Lab on a chip·2024
Same author

Droplet-Based Microfluidics Reveals Insights into Cross-Coupling Mechanisms over Single-Atom Heterogeneous Catalysts.

Angewandte Chemie (International ed. in English)·2024
Same author

Real-time, smartphone-based processing of lateral flow assays for early failure detection and rapid testing workflows.

Sensors & diagnostics·2023
Same author

Exploiting Reaction-Diffusion Conditions to Trigger Pathway Complexity in the Growth of a MOF.

Angewandte Chemie (International ed. in English)·2021
Same author

Biomimetic Synthesis of Sub-20 nm Covalent Organic Frameworks in Water.

Journal of the American Chemical Society·2020
Same journal

Microreactors for continuous processing – How close to commercial utility?

Current opinion in drug discovery & development·2010
Same journal

Synthesis of polyketide natural products and analogs as promising anticancer agents.

Current opinion in drug discovery & development·2010
Same journal

Enantioselective synthesis of substituted oxindoles and spirooxindoles with applications in drug discovery.

Current opinion in drug discovery & development·2010
Same journal

Eliminating pharmaceutical impurities: Recent advances in detection techniques.

Current opinion in drug discovery & development·2010
Same journal

Stereoselective heterocycle synthesis through oxidative carbon-hydrogen bond activation.

Current opinion in drug discovery & development·2010
Same journal

Catalysis in aqueous media for the synthesis of drug-like molecules.

Current opinion in drug discovery & development·2010
See all related articles

Microfluidic reactor technology enables ultra-high-throughput synthesis for drug discovery. These microscale systems offer efficient molecular synthesis, accelerating the production of pure drug candidates.

Area of Science:

  • Medicinal Chemistry
  • Chemical Engineering
  • Drug Discovery

Background:

  • Modern drug discovery demands rapid synthesis of pure drug candidates.
  • Combinatorial chemistry requires efficient and high-throughput synthetic technologies.
  • Microfluidic reactor technology presents a novel solution for these demands.

Purpose of the Study:

  • To review the unique advantages of microfluidic systems for molecular synthesis.
  • To detail recent advancements in microfluidic reactor technology for chemistry.
  • To assess the practical application of micro-engineered reactors in high-throughput synthesis.

Main Methods:

  • Review of current literature on microfluidic reactors in synthesis.
  • Analysis of microfluidic systems' capabilities for solution-phase chemistry.

Related Experiment Videos

  • Evaluation of efficiency and purity in microscale molecular synthesis.

    • Main Results:

    • Microfluidic reactors provide unique environments for high-efficiency synthesis.
    • Recent developments show significant progress in microfluidic reactor applications.
    • These systems offer a promising approach for ultra-high-throughput compound synthesis.

    Conclusions:

    • Microfluidic technology is a valuable tool for modern combinatorial chemistry.
    • Microscale systems facilitate the rapid production of highly pure drug candidates.
    • Further development and adoption of microfluidic reactors are crucial for accelerating drug discovery timelines.