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Updated: Aug 20, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Toward a commercial synthesis of (+)-discodermolide
1Novartis Pharma AG, Chemical and Analytical Development, CH 4002 Basel, Switzerland. stuart_john.mickel@pharma.novartis.com
Abstract:
In this review some of the criteria required for a viable chemical (+)-discodermolide production process are discussed by critical evaluation of the available literature approaches. A further route involving the use of polyketide synthase to produce (+)-discodermolide fragments by fermentation is also described. Both approaches have advantages and disadvantages and require significant optimization in order to achieve commercialization of this important natural product.
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