Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Itraconazole formation using supercritical carbon dioxide.

Ali Hassan1, Yi-Min Tang, James W Ayres

  • 1Department of Chemical and Petroleum Engineering, UAE University, Al-Ain, United Arab Emirates. hassana@uaeu.ac.ae

Drug Development and Industrial Pharmacy
|December 15, 2004
PubMed
Summary

A novel method uses supercritical carbon dioxide (SC CO2) to prepare Itraconazole, an antifungal drug, without toxic solvents. This green chemistry approach enhances drug dissolution and potentially reduces side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autologous Fat Grafting Versus Facial Fillers in Facial Cosmesis: A Systematic review and Meta-analysis.

Aesthetic plastic surgery·2026
Same author

Trends and disparities in HIV before and after COVID-19 from 1999 to 2023.

Annals of medicine and surgery (2012)·2026
Same author

Impact of Ventilator-Associated Pneumonia on Clinical Outcomes in a Pediatric Intensive Care Unit: A Retrospective Cohort Study From Lahore, Pakistan.

Cureus·2026
Same author

Corrigendum to "A comprehensive study on mechanisms of action of fibroin, aloe vera, and ginger extracts through histochemical, inflammation biomarkers, and matrix metalloproteinases analysis against diabetic wounds" [J Tissue Viability 33 (2024) 949-959].

Journal of tissue viability·2026
Same author

A rare case of complete agenesis of the left hemidiaphragm in a 17-year-old male: modified surgical reconstruction and literature review.

Annals of medicine and surgery (2012)·2026
Same author

Long-term Real-world Safety and Efficacy of Cladribine Tablets in Patients with Relapsing-Remitting Multiple Sclerosis: The UAE Experience.

Multiple sclerosis and related disorders·2026

Area of Science:

  • Pharmaceutical Chemistry
  • Green Chemistry
  • Chemical Engineering

Background:

  • Itraconazole is a synthetic triazole antifungal agent.
  • Conventional Itraconazole preparation involves toxic organic solvents.
  • There is a need for safer and more effective drug preparation methods.

Purpose of the Study:

  • To develop a new method for preparing Itraconazole using supercritical carbon dioxide (SC CO2).
  • To eliminate the use of toxic solvents in Itraconazole synthesis.
  • To enhance the dissolution properties of Itraconazole in gastric fluid.

Main Methods:

  • Supercritical carbon dioxide (SC CO2) extraction was employed for Itraconazole preparation.
  • Optimization of operating conditions including temperature (110-140°C), pressure (30-400 atm), and time (10-60 min).

Related Experiment Videos

  • Dissolution testing in gastric fluid was performed and compared to conventional formulations.

    • Main Results:

    • 100% Itraconazole dissolution in gastric fluid within one hour was achieved under optimized conditions (135°C, 300 atm, 30 min).
    • The SC CO2 process yielded a 10% higher dissolution extent compared to conventional methods.
    • The produced Itraconazole showed no degradation during the solvent-free preparation.

    Conclusions:

    • Supercritical carbon dioxide offers a viable, green alternative for Itraconazole preparation.
    • This method enhances drug dissolution and minimizes potential side effects.
    • The solvent-free approach represents a significant advancement in antifungal drug manufacturing.