Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

B-lymphocytes, innate immunity, and autoimmunity.

Muriel Viau1, Moncef Zouali

  • 1Institut National de Santé et de Recherche Médicale (INSERM U 430), Immunopathologie Humaine, 75006 Paris, France.

Clinical Immunology (Orlando, Fla.)
|December 15, 2004
PubMed
Summary

Innate-like B cells, such as B-1 and marginal zone (MZ) B cells, link innate and adaptive immunity. Their role in autoimmunity suggests targeted B cell depletion may treat autoimmune diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Community series in SARS-CoV-2 variants, B lymphocytes, and autoreactivity, volume II.

Frontiers in immunology·2026
Same author

Inverse Vaccination for Autoimmune Diseases: Insights into the Role of B Lymphocytes.

Cells·2025
Same author

Cellular pathways and molecular events that shape autoantibody production in COVID-19.

Journal of autoimmunity·2024
Same author

Swaying the advantage: multifaceted functions of inflammasomes in adaptive immunity.

The FEBS journal·2024
Same author

Inflammasome functional activities in B lymphocytes.

Immunologic research·2024
Same author

Engineered immune cells as therapeutics for autoimmune diseases.

Trends in biotechnology·2024

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • B lymphocytes are key to adaptive immunity, generating specific responses and memory.
  • B-1 cells and marginal zone (MZ) B cells exhibit innate-like functions, responding rapidly to antigens.
  • These B cell subsets link innate and adaptive immunity through secreted factors and Toll-like receptor (TLR) expression.

Purpose of the Study:

  • To investigate the role of innate-like B cells in autoimmune disease pathogenesis.
  • To explore the potential of targeting B-1 and MZ B cells for autoimmune disorder treatment.

Main Methods:

  • Review of experimental models of autoimmunity.
  • Analysis of B cell behavior, including sequestration in the MZ and autoantibody secretion.
  • Evaluation of B cell depletion therapies in autoimmune contexts.

Related Experiment Videos

Main Results:

  • Innate-like B cells, particularly MZ B cells, are implicated in autoimmune disease pathogenesis.
  • Their low activation threshold makes them reactive to self-antigens, potentially worsening autoimmunity.
  • Expansion of these cells and autoantibody production correlate with tissue damage in autoimmune models.

Conclusions:

  • Targeting B-1 and MZ B cells may offer a more efficient strategy for treating systemic autoimmunity.
  • B cell depletion therapies show promise for autoimmune disorders, with specific B cell subset elimination as a potential advancement.