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Published on: December 18, 2016
Correlation between antemortem magnetic resonance imaging findings and pathologically confirmed corticobasal
Keith A Josephs1, David F Tang-Wai, Steven D Edland
1Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. josephs.keith@mayo.edu
Background:
Slowly progressive asymmetric parkinsonism and cortical dysfunction clinically characterize corticobasal syndrome (CBS). Various pathologic findings, including corticobasal degeneration (CBD), progressive supranuclear palsy, and frontotemporal degenerations, underlie CBS.
Objective:
To determine if regional cortical and corpus callosum atrophy and subcortical and periventricular white matter (SPWM) signal changes on head magnetic resonance imaging were specific to CBD.
Design:
Historical review of autopsy cases.
Setting:
Subspecialized behavioral neurology and movement disorder clinics within a neurology department of a tertiary referral center.
Patients:
Seventeen patients with CBS who had an autopsy-confirmed diagnosis of CBD or another neurodegenerative disease.
Main Outcome Measures:
Regional cerebral cortical atrophy, regional corpus callosum atrophy, and SPWM signal changes.
Results:
Similar patterns of regional atrophy and SPWM signal changes were found in the patients with autopsy-proven CBD and in the patients with other neurodegenerative diseases.
Conclusion:
Neither cortical nor corpus callosum atrophy nor SPWM signal changes on head magnetic resonance imaging are specific to CBD.
