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Somatic cell mapping of bovine EC-SOD and SOD1L loci
D S Gallagher1, L S Gibbs, J B Shaffer
1Department of Veterinary Pathobiology, Texas A & M University, College Station 77843-4463.
Genomics
|March 11, 1992
Abstract:
cDNA probes of human extracellular superoxide dismutase (EC-SOD) and bovine superoxide dismutase 1 (SOD1) genes were hybridized to Southern blots containing genomic DNAs from cow-rodent somatic cell lines segregating bovine chromosomes. The SOD1 probe identified two loci: the coding locus (SOD1), which mapped to bovine U10; and a related locus (SOD1L), which mapped to U11. EC-SOD mapped to bovine U15. The mapping of EC-SOD to human chromosome 4, and our mapping of EC-SOD to U15, further defines a region of extensive syntenic conservation between humans and domestic cows.