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[Excitotoxicity: theories and diseases]
Alejandro Ferrero1, Marina Cereseto
1UBA, Junín 956, 5to piso, 1113 Ciudad autónoma de Buenos Aires. aferrero@ffyb.uba.ar
Vertex (Buenos Aires, Argentina)
|December 15, 2004
Summary
Excitotoxic cell death, triggered by glutamate receptors, involves unknown intracellular pathways. This review explores these pathways, their link to neurodegenerative diseases, and potential anti-excitotoxic treatments.
Area of Science:
- Neuroscience
- Cell Biology
Context:
- Excitotoxic cell death results from glutamate receptor overactivation.
- Key events include increased intracellular calcium and enzyme activation.
- Specific intracellular death pathways remain largely unknown.
Purpose:
- To review current theories on excitotoxic cell death mechanisms beyond receptor interaction.
- To connect excitotoxicity to the etiology and progression of human neurodegenerative diseases.
- To describe anti-excitotoxic agents and their mechanisms of action.
Summary:
- This article synthesizes knowledge on excitotoxic cell death, focusing on intracellular pathways.
- It examines the role of excitotoxicity in neurodegenerative conditions.
- It discusses therapeutic strategies involving anti-excitotoxic agents.
Impact:
- Provides a comprehensive overview of excitotoxicity research.
- Highlights the link between excitotoxicity and neurodegeneration.
- Informs the development of novel therapeutic interventions for neurological disorders.