Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histamine H3-receptor isoforms.

R A Bakker1

  • 1Leiden/Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands. RA.Bakker@few.vu.nl

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|December 15, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors.

Diabetes, obesity & metabolism·2011
Same author

In vitro pharmacology of clinically used central nervous system-active drugs as inverse H(1) receptor agonists.

The Journal of pharmacology and experimental therapeutics·2007
Same author

8R-lisuride is a potent stereospecific histamine H1-receptor partial agonist.

Molecular pharmacology·2004
Same author

Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling.

Molecular pharmacology·2001
Same author

Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28.

The Journal of biological chemistry·2000
Same author

Constitutive activity of G protein coupled receptors and drug action.

Pharmaceutica acta Helvetiae·2000
Same journal

A platelet-monocyte pyroptotic axis mediates uremic cardiomyopathy: critical role of PF4 and hematopoietic caspase-1.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same journal

Single-cell transcriptomic analysis identifies a MIF-driven keratinocyte-macrophage-Th2 axis as a key inflammatory circuit in atopic dermatitis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same journal

Agmatine induces mitophagy via the PTS-I2R pathway to increase autophagic flux and attenuate sepsis-induced intestinal epithelial cell apoptosis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same journal

Eosinophil cationic protein-driven type 2 inflammation impairs olfactory function in a murine model.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same journal

Spleen-associated macrophage alterations and embryo viability in a murine model of recurrent spontaneous abortion.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
Same journal

Chronic intermittent hypoxia sustains the low-grade inflammatory memory of monocytes via activation of myelopoiesis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2026
See all related articles

Histamine (HA) acts as a neurotransmitter in the brain, influencing emotion, cognition, and feeding. Discoveries of histamine H3 receptor isoforms and the H4 receptor are driving therapeutic development.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Histamine (HA) is increasingly recognized for its roles as a neurotransmitter and neuromodulator in brain functions.
  • These functions include emotion, cognition, and feeding behaviors.

Purpose of the Study:

  • To review recent discoveries concerning histamine receptors.
  • To discuss the histamine H3 receptor as a therapeutic target.

Main Methods:

  • Cloning of histamine H3 receptor and its isoforms from various species.
  • Cloning of the histamine H4 receptor.
  • Analysis of differential brain expression patterns and signaling properties of H3 receptor isoforms.

Main Results:

  • Identification of multiple histamine H3 receptor isoforms with distinct expression and signaling profiles.

Related Experiment Videos

  • Characterization of the histamine H4 receptor.

    • Conclusions:

    • The histamine H3 receptor exhibits diverse isoforms with varied brain distribution and functions.
    • These findings highlight the H3 receptor's potential as a target for novel therapeutics.