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Simplified experimental human dermatophytosis model.

R Aly1, H I Maibach, I Ho

  • 1Department of Dermatology, University of California Medical Center, San Francisco.

International Journal of Dermatology
|February 1, 1992
PubMed
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This study developed a new method for creating localized fungal skin infections to compare antifungal treatments. Ciclopirox olamine lotion and cream showed similar effectiveness in treating these infections.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Standardized methods for inducing localized mycotic skin infections are needed for comparing topical antifungal agents.
  • Previous methods for infection induction were complex or less reliable.

Purpose of the Study:

  • To develop and validate a simplified method for creating localized fungal skin infections in human volunteers.
  • To compare the bioequivalency and efficacy of two ciclopirox olamine formulations (lotion and cream) in treating these induced infections.

Main Methods:

  • Healthy volunteers with negative Trichophytin tests were inoculated with Trichophyton mentagrophytes on forearms.
  • Induced localized lesions were treated twice daily for 14 days with ciclopirox olamine lotion, cream, or their vehicles.
  • Infection resolution was assessed through clinical signs, symptoms, and culture documentation.

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Main Results:

  • The developed method effectively induced localized, non-spreading fungal skin lesions.
  • No significant differences were observed in cure rates or symptom alleviation between ciclopirox olamine lotion and cream.
  • Both ciclopirox olamine formulations demonstrated significantly better efficacy than their respective vehicles.

Conclusions:

  • The authors' novel method is effective and suitable for inducing localized mycotic skin infections for therapeutic studies.
  • Ciclopirox olamine lotion and cream are bioequivalent in treating T. mentagrophytes-induced skin infections.
  • This model provides a reliable platform for future antifungal drug comparative studies.