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Recent advances in microemulsion electrokinetic chromatography
Alex Marsh1, Brian Clark, Margo Broderick
1GlaxoSmithKline R&D, New Frontiers Science Park South, Harlow, Essex, UK. alex.c.marsh@gsk.com
Electrophoresis
|December 15, 2004
Summary
Microemulsion electrokinetic chromatography (MEEKC) utilizes oil-in-water or water-in-oil microemulsions for separations. This review covers microemulsion types, compositions, and operating variables impacting MEEKC performance.
Area of Science:
- Analytical Chemistry
- Separation Science
Background:
- Microemulsion electrokinetic chromatography (MEEKC) is an electrodriven separation technique.
- Traditionally, separations use oil-in-water microemulsions stabilized by surfactants and cosurfactants.
Purpose of the Study:
- To summarize microemulsion types and compositions used in MEEKC.
- To review applications of MEEKC, focusing on recent literature (2002-2004).
- To describe the effects of operating variables on MEEKC performance.
Main Methods:
- Review of scientific literature from 2002-2004 on microemulsion electrokinetic chromatography.
- Analysis of different microemulsion formulations (oil-in-water and water-in-oil).
- Examination of key operating variables: pH, surfactant, cosurfactant, oil phase, buffer, additives, temperature, and organic modifiers.
Main Results:
- MEEKC can utilize both oil-in-water and water-in-oil microemulsions.
- Various microemulsion compositions and their applications in MEEKC are presented.
- The influence of operating parameters on separation efficiency and performance is detailed.
Conclusions:
- MEEKC is a versatile electrodriven separation technique with adaptable microemulsion systems.
- Understanding the impact of operating variables is crucial for optimizing MEEKC separations.
- Recent advancements include the exploration of water-in-oil microemulsions for novel MEEKC applications.