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Paranasal sinus mycoses.

A Chakrabarti1, S C Sharma

  • 1Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh.

The Indian Journal of Chest Diseases & Allied Sciences
|December 16, 2004
PubMed
Summary
This summary is machine-generated.

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See all related articles

Fungal sinusitis, or paranasal sinus mycoses, presents in various forms, commonly affecting young, healthy individuals. Aspergillus flavus is the most frequent cause, with treatment varying by disease type.

Area of Science:

  • Medical Mycology
  • Otolaryngology
  • Infectious Diseases

Background:

  • Paranasal sinus mycoses (fungal sinusitis) exhibit varied incidence globally, particularly in arid climates.
  • The disease is classified into allergic, non-invasive, invasive, and fulminant types, with a potential non-invasive destructive category.

Purpose of the Study:

  • To prospectively categorize 176 fungal sinusitis cases based on clinical, radiological, histopathologic, and mycologic findings.
  • To identify common etiological agents and assess treatment outcomes for different fungal sinusitis types.

Main Methods:

  • Prospective study of 176 patients with fungal sinusitis.
  • Utilized clinical, radiological, histopathologic, and mycologic evaluations for categorization.
  • Identified fungal isolates and correlated antibody presence with disease progression.

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Main Results:

  • Categorized patients into allergic (12), non-invasive without bone destruction (81), non-invasive destructive (16), chronic invasive (55), and fulminant (12) types.
  • Aspergillus flavus was the most common isolate (80%), followed by Aspergillus fumigatus (9.7%).
  • Non-invasive disease requires surgery; invasive types benefit from adjuvant therapy, with itraconazole showing efficacy in preventing recurrence.

Conclusions:

  • Fungal sinusitis affects young, immunocompetent individuals, except for the fulminant type.
  • Accurate diagnosis through histopathology and imaging is crucial for effective management.
  • Treatment strategies should be tailored to the specific type of fungal sinusitis, with surgical intervention and antifungal therapy being key components.