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Related Experiment Videos

[Inflammation and its regulatory system].

Kazuhiro Abeyama1, Ikuro Maruyama

  • 1Department of Preventive Medicine (SNBL Funded), Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 16, 2004
PubMed
Summary

Sepsis and systemic inflammatory response syndrome (SIRS) involve high mobility group box-1 (HMGB1) protein, a key mediator of inflammation and lethality. A novel therapeutic strategy involves functional HMGB1 inhibition using thrombomodulin for sepsis/SIRS/DIC.

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Area of Science:

  • Biochemistry
  • Immunology
  • Pathophysiology

Context:

  • Sepsis, also known as systemic inflammatory response syndrome (SIRS), is a significant cause of morbidity and mortality.
  • High mobility group box-1 (HMGB1) protein, typically a nuclear structural protein, acts as a late mediator in sepsis pathogenesis.

Purpose:

  • To review the general features of sepsis.
  • To elucidate the role of HMGB1 in the mechanisms driving systemic inflammation during sepsis.
  • To introduce a novel therapeutic approach targeting HMGB1.

Summary:

  • HMGB1 is released from damaged cells or secreted by immune cells, contributing to sepsis-induced lethality and cytokine release.
  • The review focuses on HMGB1's function as a pro-inflammatory mediator in sepsis.

Related Experiment Videos

  • A new therapeutic concept, "Functional HMGB1 inhibition with thrombomodulin," is presented as a potential treatment for sepsis, SIRS, and disseminated intravascular coagulation (DIC).

    • Impact:

    • Provides a comprehensive overview of sepsis mechanisms involving HMGB1.
    • Highlights a promising new therapeutic strategy for managing sepsis and related conditions.
    • Contributes to understanding HMGB1's role in inflammatory diseases and potential therapeutic interventions.