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[Correlation between intravascular coagulation/fibrinolysis system and cytokines]
Yotaro Shinozawa1, Xiao Qi Xie, Tomoyuki Endo
1Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Tohoku University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 16, 2004
Summary
Bacterial infections trigger complex cytokine responses, impacting blood coagulation and fibrinolysis. Targeting interleukin-10 (IL-10) or enhancing fibrinolysis may treat sepsis-induced hypercoagulopathy.
Area of Science:
- Immunology and Hematology
- Microbiology and Infectious Diseases
Context:
- Bacterial factors initiate significant immune and hemostatic system dysregulation.
- Cytokines play dual roles in inflammation, coagulation, and fibrinolysis during infection.
Purpose:
- To elucidate the intricate interplay between bacterial stimuli, cytokines, and the coagulation/fibrinolysis cascade.
- To identify key molecular targets for managing sepsis-associated hypercoagulopathy and impaired fibrinolysis.
Summary:
- Bacterial infections induce tissue factor and a spectrum of cytokines (e.g., TNF, IFN-gamma, IL-1beta, IL-8, IL-6, IL-10, IL-4, IL-13, TGF-beta) that differentially regulate inflammation, coagulation, and fibrinolysis.
- Specific cytokines like IL-10 are implicated in sepsis-induced hypercoagulopathy and impaired fibrinolysis, suggesting therapeutic potential.
- Activated protein C (APC) exhibits anti-inflammatory properties, offering a novel therapeutic avenue for SIRS/sepsis.
Impact:
- Provides a comprehensive overview of cytokine-mediated hemostatic imbalance in sepsis.
- Highlights potential therapeutic strategies, including IL-10 inhibition and fibrinolytic therapy.
- Underscores the emerging role of APC in treating sepsis-related coagulation disorders.