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Updated: Aug 20, 2026

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
Published on: February 20, 2021
[Evaluation of severity for systemic inflammatory response syndrome and sepsis]
Tomohiro Kurihara1, Seitaro Fujishima, Naoki Aikawa
1Department of Emergency and Critical Care Medicine, Keio University School of Medicine.
Abstract:
Systemic inflammatory response syndrome (SIRS) is defined by four simple clinical and laboratory indices and now widely accepted for diagnosing sepsis. However, since the SIRS criteria include patients with a wide range of severity, other parameters are necessary to evaluate the severity and outcome of the patients. In this review, we discussed several methods to estimate the severity of SIRS, such as number of positive SIRS indices among four, duration of SIRS, plasma IL-6 and procalcitonin, etc.
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