Related Experiment Video
Updated: Aug 20, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
[Multiple extrahepatic manifestations in a patient with chronic hepatitis C treated with interferon-alfa]
Nicola Napoli1, Cosimo Tortorella, Maria Teresa Deramo
1Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, Sezione di Medicina Interna, Università, Bari. n.napoli@intmed.uniba.it
Abstract:
The case of a 61-years-old female patient with chronic hepatitis C who developed multiple consecutive extrahepatic manifestations is reported. One of these manifestations (lichen planus) appeared before HCV-related chronic hepatitis was diagnosed and treated with interferon-alpha, suggesting that it was likely associated with HCV itself. Other manifestations appeared during IFN-alpha treatment (polyarthritis) or after the end of treatment (ulcerative cholitis, sarcoidosis) implying a role for either HCV or IFN-alpha treatment in the pathogenesis of extrahepatic manifestations.
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Hepatitis
Cirrhosis I: Introduction
Cirrhosis II: Pathophysiology
Chronic Kidney Disease II: Clinical Manifestations
Viral Hepatitis I: Introduction
