Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Split liver transplantation: past, present and future.

J S Kim1, D C Broering, R Y Tustas

  • 1Department of Hepatobiliary Surgery and Transplantation Center, Department of Pediatrics, University-Hospital Eppendorf, University of Hamburg, Hamburg, Germany.

Pediatric Transplantation
|December 16, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective.

Clinical and experimental immunology·2015
Same author

Complement and macrophage crosstalk during process of angiogenesis in tumor progression.

Journal of biomedical science·2015
Same author

Transhilar passage in right graft live donor liver transplantation: intrahilar anatomy and its impact on operative strategy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2012
Same author

Palliative partial pancreaticoduodenectomy impairs quality of life compared to bypass surgery in patients with advanced adenocarcinoma of the pancreatic head.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2011
Same author

TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer.

European journal of cancer (Oxford, England : 1990)·2011
Same author

Drainage of esophageal leakage using endoscopic vacuum therapy: a prospective pilot study.

Endoscopy·2010
Same journal

Living-Donor Kidney Transplantation Between Mother and Son With Clinically Confirmed Hereditary Angioedema.

Pediatric transplantation·2026
Same journal

EXPRESSION OF CONCERN: Tacrolimus-Related Seizure After Pediatric Liver Transplantation - A Single-Center Experience.

Pediatric transplantation·2026
Same journal

Early Neurological Complications Following Pediatric Liver Transplantation.

Pediatric transplantation·2026
Same journal

Early Response to Therapeutic Plasma Exchange as a Prognostic Indicator in Pediatric Liver Transplant Recipients with Early Allograft Dysfunction.

Pediatric transplantation·2026
Same journal

Why Do Adolescents and Young Adults Continue to Have the Worst Kidney Transplant Outcomes?

Pediatric transplantation·2026
Same journal

International Perspectives on Pediatric Split-Liver Allocation: A Review of Policy Frameworks and the Swiss Experience.

Pediatric transplantation·2026
See all related articles

Liver splitting increases donor organs for pediatric patients, significantly reducing waitlist deaths. This surgical technique provides size-matched grafts, improving outcomes for children and adults needing liver transplants.

Area of Science:

  • Hepatology
  • Transplantation Surgery
  • Organ Donation

Background:

  • End-stage liver disease poses challenges, particularly for pediatric patients facing organ shortages.
  • Traditional whole organ transplantation struggles with size-matching for pediatric recipients.
  • Liver splitting was introduced in 1988 to address donor organ scarcity.

Purpose of the Study:

  • To evaluate the efficacy of liver splitting in expanding the donor pool.
  • To improve outcomes for pediatric liver transplant recipients.
  • To assess the impact of split liver transplantation on adult recipients.

Main Methods:

  • Dividing a donor liver into two grafts: a left lateral graft for pediatric recipients and a right extended graft for adult recipients.
  • Implementing careful donor and recipient selection criteria.

Related Experiment Videos

  • Developing advanced surgical techniques for split liver transplantation (SLT).

    • Main Results:

    • Significantly reduced pediatric pre-transplant mortality to near zero.
    • Achieved outcomes comparable to whole organ transplantation (WLT).
    • Increased the availability of liver grafts without negatively impacting the adult recipient pool.

    Conclusions:

    • Liver splitting is an effective strategy to increase donor organ availability and reduce pediatric waiting list mortality.
    • Refined SLT techniques and selection criteria have made it a viable option with excellent results.
    • Further advancements aim for customized grafts, but adult-to-adult splitting requires specialized expertise.