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Published on: November 28, 2015
Roles for gliotransmission in the nervous system
1Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Abstract:
Astrocytes were long referred to as passive cells in the central nervous system (CNS). However, the application of fluorescent Ca2+ indicators revealed their "Ca2+ excitability" in response to a variety of stimuli. Since then, evidence showing that astrocytes release chemical transmitters and can modulate synapses has led to a new integrative view of the astrocyte. While it is inarguable that astrocytes play essential roles in nervous system function, and that gliotransmission modulates synapses, a significant challenge lies in developing the appropriate experimental strategy to allow unequivocal identification of roles for gliotransmission in nervous system function.
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