Segmental waveform analysis in the diagnosis of peripheral arterial occlusive diseases

The duplex exam is widely used in the diagnosis of peripheral arterial occlusive disease. It presents some drawbacks, however, such as calcified plaques, sequential stenosis, and time-consuming examinations. A type of waveform analysis, referred to in this study as segmental analysis, was conducted to try to find solutions to these problems. Parameters of waveform analysis (peak systolic velocity, acceleration time, pulsatility, and resistance indices) taken at the common femoral and popliteal arteries in 177 arterial segments (aortoiliac and femoropopliteal) were compared to angiography results in a prospective manner. The statistical analysis showed an accuracy rate above 95% for all parameters in defining hemodynamic-significant (stenosis and occlusions) lesions in both segments. Also, a combination of measurements (parallel tests) was used to differentiate between hemodynamic-significant stenosis and occlusions, showing sensitivity and specificity rates between 84.8% and 94.8%. Findings from this study show that the hemodynamics of an arterial segment can be evaluated by segmental waveform analysis. It can also be used as a screening test for peripheral arterial occlusive diseases alone or combined with the standard duplex color exam.