Rapidly progressive glomerulonephritis: current and evolving treatment strategies
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Mark A Little1, Charles D Pusey
1Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.
Abstract:
Rapidly progressive glomerulonephritis (RPGN) must be diagnosed and treated quickly to prevent irreversible organ injury. The commonest cause of RPGN is anti-neutrophil cytoplasm antibody (ANCA) associated small vessel vasculitis, and the most severe is anti-glomerular basement membrane (GBM) antibody disease. In this review we address pathogenesis, diagnosis, treatment and outcome in these two entities, with emphasis on novel therapies.
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