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[The association between platelet activity and carotid atherosclerosis]
Xu Liang1, Feng Sun, Linjie Luo
1Department of Geriatrics, The People's Hospital of Shenzhen City, Guangdong Province, Shenzhen 518020, China.
Objective:
To assess the relationship between platelet activity marker (CD62p, CD63) and carotid atherosclerosis (CAS) and evaluate the action of platelet activity on CAS.
Methods:
One hundred and thirty-two subjects were examined with carotid ultrasound and were classified into four groups according to the severity of GAS. The patients without CAS were allocated to normal carotid artery (CA) group; the patients with intimal-medial thickness (IMT) thickened were allocated to IMT thickened group; the patients with stable carotid atherosclerotic plaque (CAP) to stable CAP group; and those with unstable carotid atherosclerotic plaque to unstable CAP group. CD62p, CD63 were measure by flow cytometry in all patients.
Results:
The serum level of CD62p was higher in the unstable CAP group as compared with that of the other three groups (P < 0.05-0.01), and the level of CD62p in the stable CAP group was higher than that of the normal CA group (P < 0.01). The serum level of CD63 in the unstable CAP group was higher than that of the normal CA group and IMT thickened group (P < 0.05) and the level of CD63 in the stable CAP group was higher than that of the normal CA group (P < 0.05). The multivariate stepwise regression analysis showed positive correlation between CD62p and CAS.