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The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
08:06

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions

Published on: February 1, 2018

Metallo-beta-lactamase inhibitors: promise for the future?

Jeffrey H Toney1, Joseph G Moloughney

  • 1Montclair State University, Department of Chemistry and Biochemistry, Richardson Hall, Room 352, 1 Normal Avenue, Upper Montclair, NJ 07043, USA. toneyje@mail.montclair.edu

Current Opinion in Investigational Drugs (London, England : 2000)
|December 17, 2004
PubMed

Insights

Carbapenem resistance threatens antibiotic effectiveness. This review highlights progress in developing metallo-beta-lactamase inhibitors to combat resistance, focusing on advancements since 2000.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Carbapenem antibiotics, including imipenem and meropenem, are losing effectiveness due to rising bacterial resistance.
  • Resistance mechanisms involve porin loss, penicillin-binding protein mutations, and beta-lactamase enzyme activity (Classes A, B, D).
  • Existing strategies to combat beta-lactam resistance include developing hydrolysis-resistant antibiotics and using beta-lactamase inhibitors.

Purpose of the Study:

  • To review progress in identifying inhibitors targeting class B metallo-beta-lactamases (MBLs) since 2000.
  • To explore strategies for reversing carbapenem resistance mediated by MBLs.

Main Methods:

  • Literature review of scientific publications from 2000 onwards.
  • Focus on research related to metallo-beta-lactamase inhibitors and carbapenem resistance mechanisms.

Main Results:

  • Significant research efforts have been directed towards developing MBL inhibitors.
  • Identification of various chemical scaffolds and strategies for MBL inhibition.

Conclusions:

  • Developing effective metallo-beta-lactamase inhibitors is crucial for restoring carbapenem efficacy.
  • Continued research is needed to translate inhibitor discoveries into clinical applications for combating carbapenem resistance.

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