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Published on: March 22, 2016
Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques
Juan C Frias1, Kevin Jon Williams, Edward A Fisher
1Imaging Science Laboratories, Department of Radiology, Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA.
Abstract:
A new contrast agent for MRI based on recombinant HDL-like nanoparticles has been prepared. It shows a great potential as a contrast agent for atherosclerotic plaques in a relative short time (24 h post-injection) as it is selective for the plaques and is an endogenous molecule. It also can distinguish between different types of plaques as the enhancement obtained is different, depending on plaque composition.

