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Updated: Jul 10, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
Published on: November 26, 2017
Distributions of inherent structure energies during aging
Ivan Saika-Voivod1, Francesco Sciortino
1Dipartimento di Fisica and Istituto Nazionale per la Fisica della Materia, Università di Roma La Sapienza, Piazzale Aldo Moro 2, I-00185 Roma, Italy.
Abstract:
We perform extensive simulations of a binary mixture Lennard-Jones system subjected to a temperature jump in order to study the time evolution of fluctuations during aging. Analyzing data from 1500 different aging realizations, we calculate distributions of inherent structure energies for different aging times and contrast them with equilibrium. We find that the distributions initially become narrower and then widen as the system equilibrates. For deep quenches, fluctuations in the glassy system differ significantly from those observed in equilibrium. Simulation results are partially captured by theoretical predictions only when the final temperature is higher than the mode coupling temperature.
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