Related Experiment Video
Updated: Aug 14, 2026

Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
Published on: March 16, 2011
Solvable biological evolution models with general fitness functions and multiple mutations in parallel
David B Saakian1, Chin-Kun Hu, H Khachatryan
1Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan.
Abstract:
In a recent paper [Phys. Rev. E 69, 046121 (2004)]], we used the Suzuki-Trottere formalism to study a quasispecies biological evolution model in a parallel mutation-selection scheme with a single-peak fitness function and a point mutation. In the present paper, we extend such a study to evolution models with more general fitness functions or multiple mutations in the parallel mutation-selection scheme. We give some analytical equations to define the error thresholds for some general cases of mean-field-like or symmetric mutation schemes and fitness functions. We derive some equations for the dynamics in the case of a point mutation and polynomial fitness functions. We derive exact dynamics for two-point mutations, asymmetric mutations, and the four-value spin model with a single-peak fitness function. The same method is applied for the model with a royal road fitness function. We derive the steady-state distribution for the single-peak fitness function.
Related Concept Videos
Inclusive Fitness
Hardy-Weinberg Principle
Mutation, Gene Flow, and Genetic Drift
Limits to Natural Selection
Genetics of Speciation
Evolution of New Traits in Microbes

