Related Experiment Videos
Clozapine withdrawal catatonia associated with cholinergic and serotonergic rebound hyperactivity: a case report
Andrew Wei-Chiang Yeh1, Joseph W Y Lee, Tsun-Chi Cheng
1Department of General and Adolescent Psychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia.
Abstract:
Catatonia as a clozapine withdrawal syndrome has not been well documented. There is only 1 case of excited catatonia described with the diagnosis made according to strict criteria. The authors report a patient who developed a catatonic stuporous state following abrupt discontinuation of clozapine, associated with features of cholinergic and serotonergic hyperactivity. The catatonic state resolved within 1 week with reinstatement of clozapine. It is suggested that serotonergic hyperactivity was involved, contributed by cholinergic rebound, in the pathogenesis of this patient's clozapine withdrawal catatonic syndrome.
Related Concept Videos
Psychosis: Goals of Pharmacotherapy
Psychosis and Antipsychotic Drugs: Overview
Mania and Antimanic Drugs: Overview
Antipsychotic Drugs: Therapeutic Uses and Side Effects
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Drug Therapy
Antianxiety Medications
Antipsychotic Drugs: Typical and Atypical Agents