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Guillain-Barre syndrome with meningoencephalitis after Campylobacter jejuni infection

Takeshi Tsugawa1, Koki Nikaido, Toshiaki Doi

  • 1Department of Pediatrics, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-ku, Sapporo 060-8543, Japan. tsugawat@sapmed.ac.jp

The Pediatric Infectious Disease Journal
|December 17, 2004
PubMed

Insights

Guillain-Barre syndrome can occur with meningoencephalitis. Early central nervous system inflammation does not rule out this neurological disorder, even with Campylobacter jejuni infection.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Guillain-Barre syndrome is an autoimmune disorder affecting the peripheral nervous system.
  • Meningoencephalitis involves inflammation of the brain and meninges, often caused by infections.
  • Differentiating these conditions can be challenging, especially in early presentations.

Observation:

  • A 14-year-old male presented with ascending muscle weakness, urinary retention, and altered consciousness.
  • Cerebrospinal fluid analysis revealed initial pleocytosis, followed by albuminocytologic dissociation.
  • Isolation of Campylobacter jejuni and positive anti-ganglioside antibodies were noted.

Findings:

  • The patient's presentation included symptoms suggestive of both meningoencephalitis and Guillain-Barre syndrome.
  • Early neurological signs, including pleocytosis, were observed.
  • The case demonstrates the potential coexistence of these conditions.

Implications:

  • This case challenges the traditional exclusion criteria for Guillain-Barre syndrome.
  • It highlights the importance of considering Guillain-Barre syndrome even with early signs of central nervous system inflammation.
  • Early diagnosis and appropriate management are crucial for patients presenting with complex neurological symptoms.

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