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Related Concept Videos

Chemiosmosis01:32

Chemiosmosis

Oxidative phosphorylation is a highly efficient process that generates large amounts of adenosine triphosphate (ATP), the basic unit of energy that drives many cellular processes. Oxidative phosphorylation involves two processes— the electron transport chain and chemiosmosis.
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The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity and heat of...
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What is Organic Chemistry?

Organic chemistry is the study of compounds of carbon called organic compounds. Organic compounds either originate from living organisms or are synthesized by chemists. A defining trait of these compounds is the presence of carbon as the principal element, which is bonded to other carbon atoms and other elements such as hydrogen, oxygen, nitrogen, and sulfur. The existence of a wide array of organic molecules is a consequence of carbon atoms’ ability to form up to four strong bonds to other...
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Related Experiment Video

Updated: Jun 19, 2026

Visualizing Single Molecular Complexes In Vivo Using Advanced Fluorescence Microscopy
11:26

Visualizing Single Molecular Complexes In Vivo Using Advanced Fluorescence Microscopy

Published on: September 8, 2009

Exploring biology with small organic molecules.

Brent R Stockwell1

  • 1Department of Biological Sciences, Columbia University, 614 Fairchild Center, MC 2406, New York, New York 10027, USA. stockwell@biology.columbia.edu

Nature
|December 17, 2004
PubMed
Summary

Researchers need new strategies to explore biological activity space using small organic molecules. Analyzing protein binding and cellular responses helps map this uncharted territory for better biological understanding.

Area of Science:

  • Chemical biology
  • Systems biology
  • Drug discovery

Background:

  • Small organic molecules are essential for biological research.
  • Current methods for exploring biological activity space are limited.
  • Systematic exploration is needed to discover novel chemical tools.

Purpose of the Study:

  • To develop strategies for systematically exploring biological activity space.
  • To enhance the discovery and application of chemical tools in biology.
  • To map the complex interactions between small molecules and biological systems.

Main Methods:

  • Analyzing protein-small molecule interactions.
  • Assessing phenotypic responses to small organic molecules.
  • Developing coordinate systems for mapping biological activity.

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Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

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Last Updated: Jun 19, 2026

Visualizing Single Molecular Complexes In Vivo Using Advanced Fluorescence Microscopy
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Internalization and Observation of Fluorescent Biomolecules in Living Microorganisms via Electroporation
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Internalization and Observation of Fluorescent Biomolecules in Living Microorganisms via Electroporation

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Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
10:49

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

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Main Results:

  • Proposed strategies for systematic exploration of biological activity space.
  • Demonstrated the importance of analyzing both binding and phenotypic data.
  • Established an analogy to celestial mapping for understanding biological-activity space.

Conclusions:

  • Systematic exploration of biological activity space is crucial for advancing biological understanding.
  • Integrated analysis of molecular interactions and cellular responses is key.
  • Novel chemical tools can be discovered and utilized more effectively through these strategies.