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Related Experiment Videos

Identification and developmental expression of Xenopus paraxis.

Hsiu-Ting Tseng1, Milan Jamrich

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston 77030, USA.

The International Journal of Developmental Biology
|December 17, 2004
PubMed
Summary

Researchers identified Xenopus paraxis, a gene crucial for vertebrate embryogenesis. This basic helix-loop-helix protein is involved in the segmentation of paraxial mesoderm into somites during development.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Vertebrate embryogenesis involves paraxial mesoderm segmentation into somites.
  • Paraxis, a basic helix-loop-helix protein, is implicated in paraxial mesoderm development.

Purpose of the Study:

  • To isolate and characterize a Xenopus orthologue of the paraxis gene.
  • To investigate the expression pattern of Xenopus paraxis during embryogenesis.

Main Methods:

  • Gene isolation techniques.
  • Expression analysis using Xenopus embryos.

Main Results:

  • Isolation of Xenopus paraxis, a homologue of the paraxis gene.
  • Xenopus paraxis is initially expressed in the presomitic paraxial mesoderm.

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  • Expression later localizes to dorsal somites and finally to the dorso-lateral region of mature somites.

    • Conclusions:

    • Xenopus paraxis plays a role in somite development and patterning.
    • The spatiotemporal expression of paraxis suggests its involvement in somite maturation.