Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignant hyperthermia: a review.

C Johnson1, K J Edleman

  • 1Department of Anesthesia, Hutzel Hospital, Wayne State University, Detroit, MI 48201.

Journal of Perinatology : Official Journal of the California Perinatal Association
|March 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stages of change for increasing fruit and vegetable consumption among adults and young adults participating in the national 5-a-Day for Better Health community studies.

Health education & behavior : the official publication of the Society for Public Health Education·1999
Same author

Screening high-risk patients for methicillin-resistant Staphylococcus aureus on admission to the hospital: is it cost effective?

Infection control and hospital epidemiology·1999
Same author

Athletes and eating disorders: the National Collegiate Athletic Association study.

The International journal of eating disorders·1999
Same author

Spinal anesthesia for cesarean section: isobaric versus hyperbaric solution.

Acta anaesthesiologica Sinica·1999
Same author

Isobaric spinal anesthesia for paraplegic patients.

Acta anaesthesiologica Sinica·1999
Same author

Extraction and high-performance liquid chromatographic separation of selected pyrene and benzo[a]pyrene sulfates and glucuronides: preliminary application to the analysis of smokers' urine.

Journal of chromatography. B, Biomedical sciences and applications·1999

Malignant hyperthermia (MH) is a rare genetic disorder triggered by anesthesia. Early diagnosis and dantrolene treatment are crucial for managing this hypermetabolic crisis.

Area of Science:

  • Anesthesiology
  • Genetics
  • Pharmacology

Background:

  • Malignant hyperthermia (MH) is a rare, life-threatening genetic myopathy.
  • First described in 1960 as a complication of general anesthesia.
  • Affects approximately 1 in 15,000 pediatric and 1 in 40,000 adult patients.

Purpose of the Study:

  • To summarize the understanding of malignant hyperthermia.
  • To outline diagnostic criteria and treatment strategies.
  • To emphasize the genetic basis and triggers of MH.

Main Methods:

  • Review of existing literature on malignant hyperthermia.
  • Description of diagnostic methods, including the caffeine-halothane contracture test.
  • Explanation of the pathophysiology involving calcium ion release.

Related Experiment Videos

Main Results:

  • MH is triggered by halogenated anesthetics and depolarizing muscle relaxants.
  • Classic symptoms include muscle rigidity, metabolic acidosis, and fever.
  • Genetic transmission can be autosomal dominant or recessive.

Conclusions:

  • Early recognition and prompt treatment with dantrolene are vital.
  • Genetic susceptibility testing is key for at-risk individuals.
  • Understanding MH pathophysiology aids in prevention and management.