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Angina pectoris: a review of current and emerging therapies
1Department of Medicine, Queen's University.
Insights
Angina pectoris, a symptom of ischemic heart disease, affects millions. While treatments exist, revascularization surgeries are increasing, prompting exploration of novel therapies like spinal cord stimulation and gene therapy.
Area of Science:
- Cardiology
- Ischemic Heart Disease Management
Background:
- Angina pectoris is a significant symptom of ischemic heart disease, impacting millions in the US.
- Current pharmacologic treatments are insufficient, as evidenced by rising revascularization surgery rates.
Purpose of the Study:
- To review current and emerging management strategies for angina pectoris.
- To highlight alternative and advanced therapies beyond traditional treatments.
Main Methods:
- Literature review of existing pharmacologic treatments.
- Exploration of novel management strategies including device-based and genetic therapies.
Main Results:
- Despite available medications, revascularization surgeries are on the rise.
- Several innovative treatments are under investigation for refractory angina.
Conclusions:
- There is a growing need for effective angina management strategies.
- Emerging therapies like spinal cord stimulation and gene therapy show promise for ischemic heart disease.
Abstract:
Angina pectoris is a debilitating indication of the presence of ischemic heart disease that affects millions of Americans. Although a number of pharmacologic treatments are available, the annual number of revascularization surgeries continues to rise in the United States. Other management strategies, such as spinal cord stimulation, enhanced external counterpulsation, metabolic modulators, and gene therapy, are being explored.
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