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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
[Complication of NSAIDs treatment in gastrointestinal tract]
Stanisław Wojtuń1, Jerzy Gil, Grazyna Klupińska
1Klinika Gastroenterologii CSK MON WIM w Warszawie.
Abstract:
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the common medicaments administered to relieve pain and other inflammation symptoms. Apart from indisputable advantages, the use of these can cause the undesired complications especially concerning gastrointestinal tract. Some of them could be serious. The most disturbing is that some of the gastrointestinal tract damage done by NSAIDs is asymptomatic. It is imperative to identify risk factors in patients who use NASIDs and to undertake the appropriate preventive measures. Nowadays it is possible to implement prophylaxis and to avoid complications and to improve the safety profile. In this paper authors presented conditions under which the complications of use of NSAIDs could appear and the possible prophylactic measures that could be undertaken. The most common is the use of proton pump inhibitor.
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