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Updated: Aug 18, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Sleep apnea and hormone replacement therapy: a pilot study and a literature review
Jan Wesström1, Jan Ulfberg, Staffan Nilsson
1Department of Obstetrics and Gynecology, Falu Hospital, and Centre for Clinical Research Dalarna Falun, Sweden. jan.wesström@ltdalarna.se
Background:
Sleep apnea syndrome (SAS) is a common condition and a risk factor of cardiovascular and cerebrovascular diseases. The purpose of this pilot study was to investigate the effect of a gestagen (trimegeston) and estradiol hormone combination on perimenopausal and postmenopausal women with SAS.
Methods:
Four postmenopausal and one perimenopausal women were studied by polysomnography before and after treatment with hormone replacement therapy (HRT).
Results:
The subjects had a mean reduction of the severity of their sleep apnea by 75% measured by apnea/hypopnea index.
Conclusions:
HRT might be an alternative in the treatment of SAS.
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