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Published on: January 27, 2016
Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups
Bas Wels1, John A W Kruijtzer, Keith M Garner
1Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
Abstract:
The synthesis of potential beta-turn mimetics based on cyclic sulfonamide peptoid/peptoid hybrids is described. These are readily synthesized using a solid phase protocol followed by cyclization in solution, and their suitability to combinatorial approaches is illustrated by the synthesis of a small but diversely functionalized library.
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