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Updated: Aug 20, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Potent 4-aminopiperidine based antimalarial agents
Kristin M Brinner1, Mary Ann Powles, Dennis M Schmatz
1Center for New Directions in Organic Synthesis, Chemistry Department, University of California, Berkeley, CA 94720, USA.
Abstract:
A series of compounds with potent activity against a multi-drug-resistant strain of Plasmodium falciparum, the causative agent of the deadliest strain of malaria, is described. These compounds were also tested for cytotoxicity in human foreskin fibroblast assays, evaluated to determine their logD, and assayed for metabolism by human and murine hepatocytes. This work resulted in the development of compounds 9e and 10d, which showed good potency (IC(50)=75 nM and <60 nM, respectively, against Dd2), acceptable logD values, and reasonable metabolic stability.
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