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Updated: Aug 20, 2026

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Published on: June 5, 2019
[Effect of insulin on expression of whole-blood platelet membrane P-selectin]
Bi-you Peng1, Yan Zhou, Wei-ren Dong
1Clinic of Dongkeng Labor Reeducation Camp, Justice Bureau of Guangzhou, Guangzhou 510515, China. pengbiyou@fm365.com
Objective:
To investigate the effects of insulin on the expression of whole-blood platelet membrane P-selectin.
Methods:
Flow cytometry (FCM) was used to detect the expression of whole-blood platelet membrane P-selectin, and the effect of insulin on the expression on quiescent and activated plasma platelet observed in normal young subjects.
Results:
Insulin had no effect on the P-selectin expression on quiescent platelet membrane, but significantly inhibited the up-regulation of P-selectin expression induced by thrombin and collagen respectively, exhibiting dose- and time-dependent effects.
Conclusion:
Insulin can inhibit P-selectin expression on activated platelet membrane.
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