Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemoreflex and metaboreflex control during static hypoxic exercise.

Anne Houssiere1, Boutaina Najem, Agniezka Ciarka

  • 1Dept. of Physiology, Faculty of Medicine, Erasme University Hospital, 808 Lennik Rd., B-1070 Brussels, Belgium.

American Journal of Physiology. Heart and Circulatory Physiology
|December 18, 2004
PubMed
Summary

Muscle metaboreceptors and chemoreceptors have different impacts on the body during exercise in low oxygen. These findings are crucial for understanding cardiorespiratory and sympathetic responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing cardiovascular risk in Belgium through practical and measurable initiatives: a multidisciplinary expert-led call to action.

Acta cardiologica·2026
Same author

Less severe endothelial injury and vascular pathway activation in SARS-CoV-2 Omicron variant compared to Alpha.

Scientific reports·2026
Same author

Heart rate variability during wakefulness reflects sleep apnea indicators but remains context-dependent.

Frontiers in physiology·2026
Same author

Interplay of pulmonary circulation, cardiac filling pressures, and sympathovagal balance in exercise-induced hyperventilation among cardiopulmonary disorders.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same author

The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension.

Cardiovascular research·2026
Same author

Estimating V̇O<sub>2</sub> max in healthy subjects without maximal effort: a novel protocol using ballistocardiography.

Frontiers in sports and active living·2026

Area of Science:

  • Exercise Physiology
  • Cardiovascular Physiology
  • Respiratory Physiology

Background:

  • Muscle metaboreceptor and chemoreceptor activation influence cardiorespiratory and sympathetic responses.
  • Understanding their combined and individual effects during exercise in hypoxia is essential.

Purpose of the Study:

  • To investigate the differential effects of muscle metaboreceptor and chemoreceptor activation during hypoxic static exercise.
  • To analyze cardiorespiratory and sympathetic nerve activity responses.

Main Methods:

  • 13 healthy subjects underwent three randomized interventions: isocapnic hypoxia, isometric handgrip exercise in normoxia, and combined exercise in hypoxia.
  • Muscle sympathetic nerve activity (MSNA), heart rate, blood pressure, ventilation, and blood lactate were recorded.

Related Experiment Videos

  • Forearm circulatory arrest followed each intervention to isolate metaboreflex and chemoreflex effects.

    • Main Results:

    • Isometric handgrip significantly increased blood pressure, MSNA, heart rate, ventilation, and lactate.
    • Hypoxia alone increased MSNA, heart rate, and ventilation, but not blood pressure or lactate.
    • Combined exercise in hypoxia potentiated blood pressure, heart rate, MSNA, and ventilation responses.

    Conclusions:

    • Metaboreceptors and chemoreceptors exert distinct influences on cardiorespiratory and sympathetic systems during exercise under hypoxic conditions.
    • The findings highlight the complex interplay between these receptor systems in regulating physiological responses to exercise stress.