Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Eukaryotic RNA Polymerases

Eukaryotic RNA Polymerases

RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...

Movement Joints in Buildings

Movement Joints in Buildings

Movement joints in buildings are essential design elements that accommodate inevitable motions caused by various factors such as temperature changes, moisture content variations, and structural deflections. These motions, if not considered in design and construction, can lead to unsightly or dangerous damage. Movement joints are incorporated in different forms to manage these stresses and allow materials to move without causing distress.
The simplest type of movement joints, working joints, are...

Types of Building Stone

Types of Building Stone

Building stones, essential materials for construction, are extracted from natural rock deposits and processed into specific forms and dimensions suitable for various building applications. These stones are broadly classified into three types based on their geological formation: igneous, sedimentary, and metamorphic.
Igneous rocks are formed from the solidification of magma or lava. An example is granite, known for its durability and resistance to weathering, making it ideal for parts of...

RNA Stability

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

RNA Interference

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

RNA Structure

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

To What Extent a Synthetic Strategy Can Influence the Structure, Molecular Dynamics, and Biological Properties of Cyclic Tryptophan Cage Miniproteins.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025

Same author

Anticancer Activity of Enantiomeric Neplanocins A: Exploring the Role of Chirality in Tumor Suppression.

International journal of molecular sciences·2025

Same author

Double-modified, thio and methylene ATP analogue facilitates wound healing in vitro and in vivo.

Scientific reports·2024

Same author

Influence of heterochirality on the structure, dynamics, biological properties of cyclic(PFPF) tetrapeptides obtained by solvent-free ball mill mechanosynthesis.

Scientific reports·2024

Same author

Identification of a novel drug molecule for neurodegenerative disease from marine algae through <i>in-silico</i> analysis.

Journal of biomolecular structure & dynamics·2024

Same author

Synthesis, anticancer activity, and molecular docking of half-sandwich iron(II) cyclopentadienyl complexes with maleimide and phosphine or phosphite ligands.

Scientific reports·2024

Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026

Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026

Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026

Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026

Same journal

Retraction.

Science (New York, N.Y.)·2026

Same journal

Making time.

Science (New York, N.Y.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 26, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Building programmable jigsaw puzzles with RNA.

Arkadiusz Chworos¹, Isil Severcan, Alexey Y Koyfman

¹Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.

Science (New York, N.Y.)

|December 18, 2004

Summary

This summary is machine-generated.

Researchers designed artificial RNA building blocks, called tectosquares, for precise molecular self-assembly. This breakthrough enables the creation of complex nanoscopic fabrics with programmable patterns and dimensions.

More Related Videos

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

Related Experiment Videos

Last Updated: Jan 26, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment

Published on: December 29, 2014

Area of Science:

Supramolecular Chemistry
RNA Nanotechnology
Materials Science

Background:

Designing self-assembling molecular building blocks is crucial for controlling matter at the nanoscale.
Current methods face challenges in achieving precise control over the arrangement and structure of assembled materials.

Purpose of the Study:

To develop versatile, artificial RNA building blocks for predictable self-assembly.
To demonstrate algorithmic control over the geometry, topology, and pattern formation of nanoscopic structures.

Main Methods:

Design and prediction of three-dimensional RNA structures.
Programming RNA building blocks (tectosquares) with specific geometric and topological features.
Algorithmic self-assembly to generate complex nanoscopic fabrics.

Main Results:

Successfully designed artificial RNA tectosquares capable of predictable self-assembly.
Demonstrated programmable control over the geometry, topology, directionality, and addressability of RNA nanostructures.
Generated complex nanoscopic fabrics with predefined periodic and aperiodic patterns.

Conclusions:

Small RNA structural motifs can dictate the topology of large molecular architectures, highlighting modularity.
Fully addressable RNA-based materials can be synthesized.
The study provides insights into the self-assembly of large populations of RNA molecules.