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Production and Use of Lentivirus to Selectively Transduce Primary Oligodendrocyte Precursor Cells for In Vitro Myelination Assays
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bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS

Heather A Arnett1, Stephen P J Fancy, John A Alberta

  • 1Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|December 18, 2004
PubMed

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Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...