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Improvement of nisin production in pH feed-back controlled, fed-batch culture by Lactococcus lactis subsp. lactis
Wenhua Lv1, Wei Cong, Zhaoling Cai
1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, P.O. Box 353, Beijing, 100080, P.R. China.
Biotechnology Letters
|December 18, 2004
Abstract:
Nisin production by Lactococcus lactis subsp. lactis in fed-batch culture was doubled by using a pH feed-back controlled method. Sucrose concentration was controlled at 10 g l(-1) giving 5010 IU nisin ml(-1) compared to 2660 IU nisin ml(-1) in batch culture.
