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Primary osteosarcoma of the breast
Hirohito Momoi1, Yasuo Wada, Shuuhei Sarumaru
1Department of Surgery, Himeji National Hospital, Japan. momoi@kuhp.kyoto-u.ac.jp
Breast Cancer (Tokyo, Japan)
|December 18, 2004
Summary
This case report details a rare primary osteosarcoma of the breast in a 58-year-old woman. Despite surgery and chemotherapy, the aggressive tumor recurred and metastasized, leading to death within months.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Primary osteosarcoma of the breast is an exceptionally rare malignant breast tumor.
- Extraskeletal osteosarcoma typically arises in soft tissues, with breast involvement being exceedingly uncommon.
Observation:
- A 58-year-old woman presented with a large, bony-hard, palpable mass in the left breast.
- Mammography revealed a round, radiopaque mass with a shaggy outline.
- Bone radionuclide scan showed limited metastases to the pelvis and scapula.
Findings:
- Histopathological examination confirmed extraskeletal osteosarcoma of the breast with lymph node metastases.
- The tumor measured 90 x 70 mm and was located in the upper outer quadrant.
- Despite modified radical mastectomy and adjuvant chemotherapy, local recurrence occurred within four months.
Implications:
- This case highlights the aggressive nature and poor prognosis of primary breast osteosarcoma.
- Early detection and novel therapeutic strategies are crucial for improving outcomes in rare breast cancers.
- Further research into the molecular mechanisms of extraskeletal osteosarcoma is warranted.