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Updated: Aug 20, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
The corticotropin-releasing factor system as a potential target for antiobesity drugs
Christian Doyon1, Arthur Moraru, Denis Richard
1Département D'Anatomie et de Physiologie, Université Laval, Québec, Canada.
Abstract:
Corticotropin-releasing factor (CRF)-related peptides are involved in numerous physiological and behavioral actions, including activation of the pituitary-adrenal axis, stimulation of anxiety-related behaviors and modulation of cardiovascular and gastrointestinal functions. They are also capable of strong anorectic and thermogenic effects. In fact, the CRF system, which promotes a negative energy profile upon activation, could represent a potential target for the pharmacological treatment of obesity. The recent identification of two endogenous ligands for the CRF(2) receptor, urocortins 2 and 3, and the development of selective CRF receptor antagonists, has paved the way for improving our understanding of the specific physiological roles played by each CRF receptor. Based on recent progress, we conclude that the CRF(2) receptor could be a potential target for the development of an antiobesity drug.
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