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Related Experiment Videos

Minimal physiologic temperature variations during renal ischemia alter functional and morphologic outcome.

T J Pelkey1, R S Frank, J J Stanley

  • 1Department of Physiology, University of Michigan Medical School, Ann Arbor 48109-0622.

Journal of Vascular Surgery
|April 1, 1992
PubMed
Summary

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Maintaining lower body temperatures during renal ischemia significantly improves kidney outcomes. Even minimal temperature increases during ischemia negatively impact kidney function and morphology, highlighting the importance of temperature control.

Area of Science:

  • Nephrology
  • Vascular Surgery
  • Physiology

Background:

  • Renal ischemia is a common complication during aortic and renal vascular reconstruction.
  • Profound hypothermia can preserve renal tissue, but is often impractical in clinical settings.
  • Renal ischemia frequently occurs at physiological temperatures, impacting outcomes.

Purpose of the Study:

  • To investigate the impact of minimal temperature changes during renal ischemia on kidney function and morphology.
  • To determine if maintaining physiological temperatures during renal ischemia affects post-ischemic outcomes.

Main Methods:

  • Adult male Sprague-Dawley rats underwent right nephrectomy and 45-minute left renal pedicle ischemia.
  • Rats were divided into three groups based on body temperature during ischemia: 35°C, 37°C, and 39°C.

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  • Creatinine levels and kidney histology were assessed post-ischemia.

    • Main Results:

    • Elevated body temperatures during ischemia led to increased plasma creatinine levels at 24 hours.
    • Histological assessment at 30 hours showed better proximal tubular morphology preservation at lower temperatures.
    • A significant difference in morphologic outcome was observed between 37°C and 39°C groups (p=0.016).

    Conclusions:

    • Minimal temperature variations during renal ischemia significantly alter functional and morphologic outcomes.
    • Lower body temperatures during renal ischemia are associated with improved renal tissue preservation.
    • These findings underscore the importance of temperature management during renal ischemia in vascular reconstruction.