[The complexation of prostaglandin E1 with hydroxylpropyl-beta-cyclodextrin in aqueous solution]

Fu-gen Gu1, Fu-de Cui, Yong-liang Gao

  • 1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.

Summary

Prostaglandin E1 (PGE1) forms a 1:1 inclusion complex with hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) in aqueous solutions, enhancing PGE1 solubility. This complexation occurs spontaneously, driven by favorable thermodynamics.

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