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[Drug therapy in the elderly].

T Ishizaki1

  • 1Clinical Research Institute, National Medical Center.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|January 1, 1992
PubMed
Summary

Elderly individuals experience more adverse drug reactions due to age-related pharmacokinetic changes. Adjusting drug dosages based on therapeutic drug monitoring is crucial for safe and effective elderly patient care.

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Area of Science:

  • Geriatric Pharmacology
  • Clinical Pharmacology
  • Drug Metabolism

Context:

  • Elderly patients exhibit increased susceptibility to adverse drug reactions.
  • Age-related physiological changes impact drug pharmacokinetics (absorption, distribution, metabolism, elimination).
  • Reduced lean body mass, total body water, renal function, and cardiac output affect drug processing.

Purpose:

  • To review the relationship between advanced age and drug pharmacokinetics, particularly for renally eliminated drugs.
  • To present methods for rational dosage regimen modifications in elderly patients with diminished renal function.
  • To emphasize the importance of therapeutic drug monitoring in geriatric pharmacotherapy.

Summary:

  • Ageing alters pharmacokinetics, influencing drug efficacy and toxicity in the elderly.
  • Physiological changes like decreased renal function and altered body composition are key factors.
  • Dosage adjustments are necessary, especially for drugs cleared by the kidneys.

Impact:

  • Provides a framework for safer and more effective drug therapy in the elderly population.
  • Highlights the critical role of individualized dosage regimens.
  • Contributes to improved clinical outcomes and reduced adverse events in geriatric patients.

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