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Updated: Aug 20, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Perioperative primary stroke: is aspirin cessation to blame?
Arash Kimyai-Asadi1, Ming H Jih, Leonard H Goldberg
1DermSurgery Associates, Houston, Texas 77030, USA. akimyai@yahoo.com
Insights
Discontinuing aspirin for primary prophylaxis before dermatologic surgery may not significantly increase thrombotic event risk. The study suggests other factors are more influential in postoperative thrombosis.
Area of Science:
- Dermatologic Surgery
- Cardiovascular Thrombosis
- Perioperative Medicine
Background:
- Thrombotic events are reported following cessation of antiplatelet and antithrombotic therapies.
- Aspirin is commonly used for primary cardiovascular prophylaxis.
Observation:
- A case of postoperative thrombotic event after dermatologic surgery in a patient withholding aspirin for primary prophylaxis is presented.
- This is the first reported case linking aspirin discontinuation to such an event in this context.
Findings:
- The study questions the direct causal link between aspirin discontinuation and thrombotic events in dermatologic surgery patients.
- High baseline risk of thrombosis in Mohs surgery patients and low risk when perioperative medications are withheld are noted.
Implications:
- The findings suggest that the decision to discontinue aspirin for primary prophylaxis before dermatologic surgery warrants careful consideration of individual patient risk factors.
- Further research is needed to clarify the precise role of aspirin discontinuation in perioperative thrombotic complications.
Background:
There are a number of reports in the literature of patients developing thrombotic events after stopping medically necessary antiplatelet and antithrombotic agents.
Objective:
The objective was to determine whether discontinuation of aspirin taken for primary prophylaxis contributes to the development of thrombotic complications in patients undergoing dermatologic surgery.
Methods:
A case is reported and the literature is reviewed.
Results:
We present the first reported case of a postoperative thrombotic event following dermatologic surgery in a patient withholding aspirin that was taken for primary prophylaxis.
Conclusion:
We believe that the available data make it difficult to implicate aspirin discontinuation in the development of each thrombotic event, given the high baseline risk of thrombotic events in the Mohs surgery patient population and the low risk of developing such events when medications are withheld perioperatively.
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